The aim of this study was to prepare nanocomposite hollow fiber membrane to achieve higher hemocompatibility and uremic toxin separation performance. Nanocomposite zeolite based hollow fiber membranes (HFMs) were synthesized using polyethersulfone (P) as a base polymer, vitamin E TPGS (T) as an additive, and nano-zeolite (NZ) as a filler. The effect of different concentration of nanozeolite was seen. Such membranes would have widespread applications, but one goal was to improve outcomes in hemodialysis for kidney failure patients. The resulting nanocomposite membranes materials (called PT-NZ) were spun based on dry-wet spinning method based on phase inversion. The additive and filler helped nodular organization of the polymer into nano-sized domains with numerous pores inbetween, and improved transport properties. They also helped with presenting a more biocompatible surface to the blood and thereby improved hemocompatibility. The PT-NZ membranes were used to fabricate modules consisting of bundles of fibers, and the modules were, in turn, fabricated into mini dialysers. The ultrafiltration coefficient of such PT-NZ HFM-based module (of about 274 mL/m2-hrmm of Hg) was about 1.5-times higher than that of the commercial (F60S) membrane (about 152 mL/m2-hr-mm of Hg). The bovine serum albumin (BSA) rejection in aqueous mixtures was found 93.98 %. The toxin clearance performance of lab-scale PT-NZ HFM-based hemodialyzer with uremic toxin spiked goat blood was remarkably higher (about 5X more reduction ratio) than that of commercial F60S hollow fibers. The newly made HFMs reported here could help in decreasing the total treatment time and reducing side-reactions during dialysis for those end stage kidney disease (ESRD) patients dependent on hemodialysis. Hence, the synthesized PT-NZ HFMs can be a potential membrane material for the hemodialysis application.