Bactericidal materials are widely pursued in the hope of counteracting the increasing prevalence of drug-resistant species. Copper, zinc and silver are metals known to effectively eliminate bacterial cultures due to their oligodynamic cytotoxic effects. Porous graphite sponges (GSs) were synthesized with two or more of these metals and are referred to herein as CuZnGS, AgCuGS, AgZnGS and AgCuZnGS each containing 7-10% total metal by mass. These GS materials were characterized with FTIR, Raman, XRD, SEM, EDXA and HRTEM. The bacterial strain E. coli, was selected as a target pathogen to observe oligodynamic properties via different exposure strategies. The bacteria were exposed to the metal GS materials and grown in a McFarland standard medium over a 48 hour period of static exposure and alternatively in the same conditions but while recirculating the liquid bacterial culture through each of the multi-metal GS samples. Measured bacterial cell count was compared to a graphite control to observe bactericidal properties.