Dust particles are directly linked to environmental and health issues, including lung cancer, leading to current environmental regulations that emphasize the development of effective dust control methods. Although a variety of suppressants composed of chemicals and polymers are used to reduce dust emission, those suppressants are commonly effective for short-term, are often corrosive to machinery, and can cause potential risks to human health due to the toxicity of chemicals in suppressant formulations. We developed biocompatible polymer formulations for environmentally friendly and long-term stable dust control methods. Some polymers are non-toxic enough to be applied to food, cosmetics, and pharmaceutical applications. Among those, we chose hydrophilic and amphiphilic liquid polymers to enhance the wettability of dust mass, thus reducing dust pollution, and investigated the effects of the liquid state and hydrophobicity of polymers to suppress dust. Hydrophilic and amphiphilic polymers of 5% or less in the formulation successfully reduced dust emission up to 95%. Even under experimental conditions that mimic extreme arid environments of 60oC, the polymers maintained their liquid state for more than two months, indicating the potential for long-term stability with the developed formulations. Interestingly, the amphiphilic polymer showed better dust suppression than the hydrophilic polymer. Using a combination of techniques, including transmission electron microscopy, Fourier-transform infrared spectroscopy, and Raman spectroscopy, we studied dust control mechanisms of liquid polymers and how the hydrophobic blocks in the amphiphilic polymer enhance dust suppression.