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Parinaz Fathi1 Fatemeh Ostadhossein1 Indu Tripathi1 Santosh Kumar Misra1 Elise Kahn1 Jasleena Singh1 Laura Selmic1 Gweniviere Capron1 Blair Rowitz1 Dipanjan Pan1

1, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States

Gastrointestinal (GI) tract perforations are relatively frequent surgical emergencies, are potentially life-threatening, and can occur from several different sources. In general, treatment requires urgent surgical repair or resection and at times can lead to further complications. Currently available stents are non-absorbable, are manufactured in a narrow size range, and/or are limited to usage in locations that are accessible for endoscopic removal post-healing. The use of 3D-printed bioresorbable polymeric stents will provide patients with a stent that is tailored specifically to their geometry, will degrade with time to eliminate the need for further surgeries for stent removal post-healing, and will be usable in locations that are not endoscopically accessible. This project focuses on the characterization of polycaprolactone-polydioxanone (PCL-PDO) composites for use in a bioresorbable gastrointestinal stent. Dynamic Mechanical Analysis (DMA) tests were conducted to separately analyze the effects of composition, the filament formation process, and physiological temperature on the PCL-PDO material properties. The proposed stent design was then modelled using computer-aided design, and Finite Element Analysis (FEA) was used to simulate the effects of physiologically relevant forces on stent integrity. In-vitro studies were used to evaluate the biocompatibility of the polymer composite. PCL-PDO stents were then 3D-printed and placed in-vivo in a pig model, and histological evaluation was used to determine the safety of these stents.

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