2, University of Leeds, Leeds, , United Kingdom
Aerogels have diverse properties that are appealing to medical applications. Combining these properties with those of natural polymers, like polysaccharides, may increase the applicability of aerogel materials in life sciences. Chitosan (Cs) and acemannan (AC) are biocompatible and biodegradable polysaccharides that can promote wound healing and may activate the immune system, inducing a faster recognition of foreign antigens (viruses, bacteria, etc.) for their elimination. A dressing type aerogel biomaterial with distinctive features suitable for wound healing could be obtained with Cs and AC. Pursuing this goal, herein is reported the formation of Cs-AC mixed aerogels and partial characterization. Physical hydrogels were obtained from several mixtures of Cs and AC. The obtained gels were dried by supercritical CO2 treatment. Morphological and diverse physicochemical characteristics were analyzed. The obtained aerogels were highly porous materials with mesoporous structures (10-40 nm pore size), low density (0.1–0.46 g/cm3) and high specific surface areas (150-300 m2/g). The obtained results suggest that these type of materials can provide high liquid absorption rates and enhanced interphase interaction in living tissues that could lead to a faster and efficient wound healing. The next goal of our investigation is to determine the biocompatibility and the ability of this aerogels to induce the production of pro-inflammatory and anti-inflammatory cytokines in different cell lines in vitro.