2, University of California, Los Angeles, Los Angeles, California, United States
3, University of California, Los Angeles, Los Angeles, California, United States
4, University of California, Los Angeles, Los Angeles, California, United States
Electrochemical transistors with printed semiconductors have been attracting attentions in the biomolecule detection with very low concentration, quantitatively due to their simple processing and universal complexation of receptors. We recently, developed quasi two-dimensional (Quasi-2D) In2O3 semiconductor-based electrochemical field-effect transistors, which showed high sensitivity and large transconductance. pH, glucose, and neurotransmitters could be detectable with high sensitivity and selectivity. pH sensitivity was reached to over 60 mV/pH that was highly compatible with nanomaterial platforms. For the glucose detecting application, we confirmed that the detecting ranges were covered within human tear’s glucose level (0.1 to 1 µM). Furthermore, our conformal device structures enabled to contact on highly rough surface as well as on an artificial eye for the smart lens applications.
We also expended to the neurochemical sensing, which were consisted with dopamine sequenced aptamers to get a strong specific binding of the small molecule. The conformational change of negative charge backbone of aptamers with the dopamine binding could overcome Debye screening length in physiological environments.