2, Federal University of São Paulo, Diadema, , Brazil
The recovery of chronic wounds, which present complications and require long periods for healing is still a challenge for medicine, since they are usually expensive processes and, in some cases, the failure of the treatment lead to amputation. Asymmetric membranes present interesting characteristics for wound healing, as the porous layer acts helping on the drainage of excess wound exudate and the dense layer (upper film) controls the transport of microorganisms and prevents the excessive loss of water. Literature presents natural polymers as good materials for production of structured membranes. Konjac glucomannan (KGM) is an example of such versatile polyssacharides that can be processed with partial drying and freezing to produce asymmetric membranes. Flexibility, resistance to handling, suitable elongation, water vapor transmission rate and fluid handling capacity are some of the recquirements that can be met by fine-tuning the processing parameters. In addition, they revealed to be non cytotoxic and capacity to prevent microbial invasion, being very interesting to support tissue repair.