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Federico Rosei1

1, INRS, Varennes, Quebec, Canada

Nanostructuring materials allows to optimize their properties, by exploiting size effects. We created nanopatterns that act as surface cues [2,3], affecting cell behavior. Chemical oxidation creates nanoscale topographies [4], that allow to improve biocompatibility. Our treatment provides a differential signal, selectively inhibits fibroblast proliferation while promoting osteoblast growth [5] in vitro. Enhancing mechano-biocompatibility may occur by coating with spider silk [6-8]. Improving antibacterial properties using laser/plasma strategies and by growing graphene oxide coatings will also be discussed [9-13]. Finally, sensing and therapeutic approaches can be harnessed by exploiting emerging optical properties of nanocrystals such as Quantum Dots and upconverting nanoparticles [14-17].
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[5] C. Brown et al., Nanoscale 3, 3805 (2011)
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[7] C. Brown et al., ACS Nano 6, 1961 (2012)
[8] C. Brown et al., J. Mater. Res. 30, 108 (2015)
[9] O. Seddiki et al., Appl Surf Sci 308, 275 (2014)
[10] M. Cloutier et al., Diam Rel Mater 48, 65 (2014)
[11] L. Cardenas et al., Nanoscale 6, 8664 (2014)
[12] M. Cloutier et al., Trends Biotechnol 33, 637 (2015)
[13] L. Cardenas et al., Nanoscale 6, 8664 (2014)
[14] Y. Huang et al., Nanoscale 7, 5178 (2015)
[15] H. Zhao et al., Small 11, 5741 (2015)
[16] C. Yan et al., Small 12, 3888 (2016)
[17] Y. Huang et al., J. Phys. Chem. B 120, 4992 (2016)

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