In the 21st century, consumers are rapidly gaining access to a novel suite of wearable electronic devices such as smart watches and garments. This technology promises both comfort and ease of use, and it also provides a wealth of health-monitoring information. Advances in the field of electronic textiles and recent achievements in organic electronics have enabled the development of new flexible and conformable technologies that can perform the same sensing as current solid state devices, for a fraction of the cost. Such progress relies on the subtle engineering of organic functional materials to model their properties. The potential of using organic ionic and electronic conducting materials in wearable monitoring systems for muscles and the heart has been evaluated. We have shown that electrodes made of such organic materials can lower contact impedance in cutaneous applications with the skin resulting in higher quality recordings compared to metal–based electrodes. Moreover, by combining these materials with textiles we have reduced the mechanical mismatch at the interface with the skin, which enables the recording of electrophysiological activities for long time intervals with an enhanced signal to noise ratio. To do so, we developed different direct patterning techniques allowing the selective deposition of organic electrodes onto fabrics. These results pave the way for the seamless integration of organic electronics and the textile platform to provide low-cost and tailored solutions in interfacing smart devices with the human body.