This contribution aims to provide an overview of some recent advances in force microscopy and its applications in nanoscience and biomedicine. The presentation covers instrumentation1-2, imaging3, nanomechanics4-6 and applications to study a wide range systems, from metal-organic-frameworks to proteins and cells in air and liquid environments. The first section is devoted to present the physics underlying the operation of an advanced force microscope. The second section provides an introduction to bimodal force microscopy. An advanced microscopy method that enables simultaneous, fast and high resolution mapping of different interfacial properties (mechanical, electrical, magnetic, optical, topography). This section describes some applications to generate atomic and molecular resolution maps of soft matter interfaces. Those maps combine topography and nanomechanical properties. The third section introduces a method to generate three dimensional and atomically-resolved maps of solid-liquid interfaces.
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2. R. Garcia, E.T. Herruzo, Nature Nanotechnol. 7, 217 (2012)
3. D. Martin-Jimenez, E. Chacon, P. Tarazona and R. Garcia, Nature Commun. 7, 12164 (2016).
4. E.T. Herruzo, A.P. Perrino and R. Garcia, Nature Commun. 5, 3126 (2014)
5. C.A. Amo, A. P. Perrino, A.F. Payam and R. Garcia, ACS Nano 11, 8650 (2017)
6. C. A. Amo and R. Garcia, ACS Nano 10, 717-7124 (2016)