Adaptive materials that respond mechanically to a stimulus are of interest for a wide range of technologies, including soft robots, responsive optoelectronics, environmental control systems, and controlled release of pharmaceutics, pesticides or antifouling agents. Typically these materials demonstrate relatively simple mechanical responses such as shrinking, expanding, or bending. The art of origami, where localized deformation at folds is used to create complex structures and mechanisms, provides an opportunity to harness the mechanical response of adaptive materials and channel it into an engineered structure. Frequently, adaptive materials are used at a hinge to demonstrate self-folding; however integration of these materials with more complex mechanical systems, and realization of possible emergent behavior, is not well understood. Using the waterbomb base, chomper and simple combinations thereof with an environmentally sensitive adaptive material, PEDOT:PSS, we demonstrate that the placement of the adaptive material dictates whether a structure undergoes fold inversion or reversible reconfiguration, such as snapthrough between bistable states. Design and behavior is understood by modeling the response of the origami system to the application of point, linear or areal forces arising from the adaptive material’s shape, location and response to the local environment. In contrast to externally applied forces, the integration of the adaptive material results in continuous force application, even during bi-stability. Following these principles, we also demonstrate autonomous reconfiguration of complex origami structures driven by the progress of the structure through different regions in its environment.