We have assembled miniaturized, brain-implantable/bio-inpsired electronics on biocompatible photocurable polysiloxane stiffer. The electronic devices and sensors show transferrable, bright, and thin micro GaN LEDs, neurotransmitter, and neural gases like NO and CO detection sensors.
In the usual optogenetic technique, the enabled modes of use are impossible to realize using standard approaches that rely on rigid, long, glass fiber optics coupled to external, bulky light sources. Our systems exploit ultrathin, flexible substrates populated with microscale inorganic light emitting diodes (LEDs) together with electrophysiological and temperature sensors, all mounted on removable plastic needles that facilitate insertion into the tissue. Detailed experimental and theoretical studies of the operation, ranging from heat flow aspects to inflammation assessments and comparison to conventional devices, illustrate the unique features of this technology. Also we exploit neural gases NO and CO change with a chronic epilepsy mouse model using injectable microscale neural gas sensors. We believe that these multifunctional, injectable electronics could be beneficial in diverse brain diseases and will open many challenging applications in areas of implantable diagnostics and therapeutics.