2, New York University, New York City, New York, United States
3, Amplipex Ltd, Szeged, , Hungary
In order to understand how behavioral and network level functions emerge from the cooperation of neuronal populations, a representative fraction of neurons must be simultaneously monitored at the single-cell level. Furthermore, in order to properly command these networks, interventions must also be temporally and spatially precisely targeted. Solutions realizing cell-type or neurotransmitter specificity regarding either the input or the output relations may add a further complementary dimension to the studies.
We developed large-scale electrophysiological recording methods that can monitor the activity of thousands of neurons simultaneously. Due to on-head analog signal multiplexing, the recorded signals are instantaneously available for driving e.g. feedback circuits, while it still provides submillisecond resolution and does not constrain the behavior of the freely moving rodents. We combine our recordings with precise optogenetic and transcranially delivered electrical manipulation approaches, which can give birth to on demand, closed-loop therapeutic interventions for many drug resistant neuropsychiatric disorders.
I will briefly introduce our recent results we gained to understand the development of hypersynchronous events in the hippocampus. Our translational work employing closed-loop transcranial electrical stimulation on human patients will be also highlighted in my talk. The goal of these efforts is to establish an acute intervention approach promptly disrupting pathologic network oscillations such as epileptic seizures. Finally, I will shortly present our attempts in developing a new generation of chemosensitive electrodes to report the concentration changes of various neuromodulators in vivo, with a comparable resolution to their secondary electrical aspects.