Steven Little1

1, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Next generation biomaterials will be capable of communicating with the biological microenvironment in ways that are similar to real cells and tissues. A primary way that this is accomplished in situ through secretion and spatiotemporal organization of soluble proteins that can lead to the homing and/or differentiation of specialized endogenous cells involved in regulation of the immune system. New technology has been made available to rationally program biomaterials in silico to produce such spatiotemporal control over release. This talk will present several examples of the programming of biomaterials to mimic the release and organization of natural proteins to achieve site-specific homing and control over the behavior of endogenous regulatory T cells toward treatments for diseases involving destructive inflammation including tissue transplantation, dry eye disease, periodontal disease, and contact dermatitis.