Yushen Jin1 Jie Tian1

1, Key Laboratory of Molecular Imaging, CAS Institute of Automation, Chinese Academy of Sciences, Beijing, , China

Early identification and treatment of hepatocellular carcinoma is very important for improving the prognosis and survival rate of the patient. A theranostic agent that combines multimodal imaging with cancer treatment may be used for aunting the visualization and treatment of the cancer. Herein, we report the synthesis of a multifunctional theranostic SP94 modified polypyrrole (PPy)-BSA-ICG nanoparticles by a simple method. The multifunctional theranostic agent exhibited two mode photoacoustic and near infrared (NIR) fluorescence imaging as well as combined with photothermal therapy. This nanoparticles showed an excellent stability in physiological solutions, a higher tumor accumulation compared with unmodified nanoparticles and minimal nonspecific uptake by other organs such as liver and spleen. And most importantly, the nanoparticles could effectively inhibit the growth of the tumor through photothermal therapy with no tumor recurrence upon only single NIR laser irradiation. These results indicated that SP94 modified PPy-BSA-ICG is potentially an interesting nanotheranostic agent for imaging guided cancer therapy by overcoming the limitations of each technology and enhancing the therapeutic efficiency as well as reducing side effects.