Temperature and biomolecular responsive hydrogels offer the possibility for the creation of smart devices that respond autonomously to physiological or environmental cues. However, it can be challenging to achieve the same level of control that can be obtained with electrically wired or pneumatic devices. In this talk, the design, fabrication and characterization of temperature and DNA responsive of soft shape change devices will be discussed including those that display programmability, multi-state and complex shape change. Gels are micropatterned using multilayer photolithography or 3D printing and swelling or collapse of gels drives shape change. Experiments are guided by mechanics and this synergy enables a high level of design. In addition to the intellectual elements, potential applications of these shape change devices will be highlighted.