3, University of California, Riverside, Riverside, California, United States
2, University of California, Riverside, Riverside, California, United States
4, University of California, Riverside, Riverside, California, United States
Fabrication of small hollow metal-oxide nanostructures has a broad application in the biomedical field with a great potential in the diagnosis and treatment of diseases like cancer. This work is focused on the synthesis and characterization of TiO2 hollow nanoparticles (TiO2 HNP). These type of nanoparticles are important in the biomedical field due to their metallic and size properties. First, with sizes smaller than cells and viruses, TiO2 HNP can be used for targeted drug delivery. The hollow nanoparticles can potentially be loaded with different therapeutic drugs, and functionalized with labels to attach and treat only damaged cells. Secondly, by exposing TiO2 HNP to a magnetic field that varies in time, they can be used for magnetic resonance imaging (MRI). Thirdly, by combining targeting treatment and MRI, TiO2 HNP can be used for theranostics.
In this work, the synthesis of TiO2 HNP was carried out using a template mediated method. Carbon spheres (CS), derived from sustainable precursors, act as a template and are synthesized by a hydrothermal process. After mixing the CS in an ethanolic solution and utilizing titanium tetraisopropoxide as the precursor, the CS are removed and the TiO2HNPs are formed and by a post- thermal treatment. The crystal structure was analyzed using X-ray diffraction (XRD). Size distribution and morphology were characterized by scanning electron microscopy (SEM). The HNP structure was verified by transmission electron microscopy (TEM).