NM06.06.03 : Antiviral and Antibacterial Inhibitors—From C-Dots to Nanodiamonds

10:45 AM–11:15 AM Apr 4, 2018

PCC North, 200 Level, Room 227 BC

Sabine Szunerits1

1, University Lille, IEMN, Villeneuve d'Ascq, , France

The constant emergence of new viruses with a global impact to public health and society at large together with the general absence of the availability of specific antiviral therapeutics for a variety of viruses have made the search for antiviral drugs and therapeutics a challenging research task. Viruses pose a considerable challenge to the body’s immune system as they hide inside cells making it difficult for antibodies to reach them. In contrast to bacterial infections, which are mostly treated using antibiotics, the immunization against viral infections is not always possible. Multivalent binding interactions have lately been considered for the development of new therapeutic strategies against bacterial and viral infections. Multivalent polymers, dendrimers and liposomes have successfully targeted pathogenic interactions. While a high synthetic effort is often needed for the development of such therapeutics, the integration of multiple ligands onto nanostructures turned to be a viable alternative. Particles modified with multiple ligands have the additional advantage of creating a high local concentration of binding molecules.
In this talk I will give several examples on the interest of carbon based nanostructures, notable C-dots and nanodiamonds for the treatment of viral and bacterial infections. Notable different glycan-modified nanodiamonds revealed themselves to be of great promise as useful nanostructures for combating microbial infections.

1. R. Jijie, A. Barras, F. Teodorescu, R. Boukherroub, S. Szunerits, Molecular Systems Design & Engineering, 2017, DOI: 10.1039/C7ME00048K, Advancements on the molecular design of nanoantibiotics: current level of development and future challenges.

2. A. Barras, F. A. Martin, O. Bande, J.-S. Baumann, J.-M. Ghigo, R. Boukherroub, C. Beloin, A. Siriwardena, S. Szunerits, Nanoscale 2013, 5, 2307-2316, Glycan-functionalized diamond nanoparticles as potent E. coli anti-adhesives.

3.M. Khanal, F. Larsonneur, V. Raks, A. Barras, R. Boukherroub, J.-M. Ghigo, C. Ortiz Mellet, V. Zaitsev, J. M. Garcia Fernandez, C. Beloin, A. Siriwardena, S. Szunerits, Nanoscale 2015, 7, 2325-2335, Inhibition of Escherichia coli adhesion to biotic surfaces and of biofilm formation on abiotic surfaces by trimeric cluster mannosides conjugated to diamond nanoparticles.

4. M. Khanal, T. Vausellin, A. Barras, O. Bande; K. Turcheniuk, M. Benazza, Zaitsev, C. M. Teodurescu, R. Boukherroub, A. Siriwardena, J. Dubuisson, S. Szunerits, ACS Applied Materials & Interfaces 2013, 5, 12488-12498, Phenyl-acid-modified nanoparticles: potential antiviral therapeutics.

5. Barras, Q. Pagneux, F. Sané, R. Boukherroub, D. Hober, S. Szunerits, ACS Applied Materials & Interfaces 2016, 13, 9004-9013, Inhibition of Herpes simplex virus type 1 entry by functional carbon nanodots.

6. S. Szunerits, A. Barras, M. Khanal, Q. Pagneux, R. Boukherroub, Molecules 2015, 20, 14051-14081, Nanostructures for the inhibition of viral infections.