NM05.08.24 : Biofuncionalization of Iron Oxide Nanoparticles with Increased DNA Interactions

5:00 PM–7:00 PM Apr 4, 2018 (America - Denver)

PCC North, 300 Level, Exhibit Hall C-E

Anya Arguelles1 Paul Zavala-Rivera1 Armando Lucero-Acuna1 Patricia Guerrero-German1 Aaron Rosas-Durazo2 Hector Cardenas-Sanchez1

1, Universidad de Sonora, Hermosillo Sonora, FDM, Mexico
2, Rubio Pharma, Hermosillo, Sonora, Mexico

Iron oxide nanoparticles (ION) have been used recently as a drug delivery system and as a contrast agent for MRI diagnosis. The ION's can work as vectors with specific surface modifications to amplify the bioactive compound effect, enhance the liberation of specific drugs or interact with certain surface as cell membranes and biomolecules [1]. This works aims to the development of ION's with surface modifications to increase the interactions with plasmid DNA (pVAX1-NH36). The objective is to synthesize ION's stabilized with hydrophobic compounds and modified with a natural flavonoid (baicalin) [2, 3], recognize as selective attractive molecule for the DNA. Probable applications are in its use for DNA mechanical purification and as an intracellular contrast agent for DNA.

[1] P. Kothamasu, H. Kanumur, N. Ravur, C. Maddu, R. Parasuramrajam, and S. Thangavel, “Nanocapsules: the weapons for novel drug delivery systems.,” Bioimpacts, vol. 2, no. 2, pp. 71–81, 2012.

[2] A. López-Millán , P. Zavala-Rivera, Reynaldo Esquivel, Roberto Carrillo, E. Alvarez-Ramos, R. Moreno-Corral , R. Guzmán-Zamudio and A. Lucero-Acuña, “Aqueous-Organic Phase Transfer of Gold and Silver Nanoparticles Using Thiol-Modified Oleic Acid”, Applied Sciences, pp. 2, 2017.

[3] Sameena Yousufa, Israel V.M.V. Enocha,b, Paulraj Mosae Selvalumara, Dhanaraj Premnathc , “Chromenone-Conjugated Magnetic Iron Oxide Nanoparticles. Toward Conveyable Dna Binders”, Colloids and Surfaces b: Biointerfaces 135, pp. 448-457, 2015.