NM05.11.33 : Light-Triggered Anticancer Activity Using Zinc Oxide Nanoparticles

5:00 PM–7:00 PM Apr 5, 2018 (America - Denver)

PCC North, 300 Level, Exhibit Hall C-E

Padmanaban Sivakumar1 Eun Ji Hong1 Yoon-Seok Kim1 Dae Gun Choi1 Min Suk Shim1

1, Incheon National University, Incheon, , Korea (the Republic of)

Zinc oxide nanoparticles (ZnO NPs) have attracted great attention due to their ability to induce the generation of reactive oxygen species (ROS) under light irradiation. In this study, light-triggered ROS generation by ZnO NPs is utilized as a new therapeutic approach for targeted cancer therapy. Poly(ethylene glycol) (PEG)-coated ZnO NPs were synthesized and further conjugated to anticancer drugs. The drug-loaded ZnO NPs were efficiently internalized by cancer cells, resulting in efficient intracellular drug delivery. The ZnO NPs also induced the formation of ROS in the cancer cells under light irradiation, leading to light-triggered cell death. Importantly, synergistic anticancer effects were achieved by combined chemotherapy and light-triggered photodynamic therapy. This study demonstrates that drug-loaded ZnO NPs are promising nanoplatforms for targeted and effective anticancer activity