Xiaodong Chen1

1, Nanyang Technological University, Singapore, , Singapore

In this talk, I will present our latest progress in using nanomechanical interfaces to influence the adaptive biomechanics of living cells during cell migration, as a way to understand cell physiology and pathology. It is a research direction emerging at the interface of nanoscience, materials science, and biomechanics. We more focus on how the nano-mechanical components including soft and hard materials modulate the cell biomechanics and consequently cell physiology or pathology at the nanoscale level. Specifically, I will present the modulated cell migration by tailoring extracellular mechanical cues, mainly the topology and interfacial apparent stiffness of underlying substrates.