This talk will provide an overview of our recent developments in the design of nanomaterials for ultrasensitive biosensing. Bio-responsive nanomaterials are of growing importance with potential applications including drug delivery, diagnostics and tissue engineering (1). Using enzyme-mediated signal readouts we have developed a suite of nanoparticle based ultrasensitive biosensing approaches as well as a cell/tissue-interfacing nanoneedle platform (2). We are applying these biosensing approaches both in high throughput drug screening and to diagnose diseases ranging from cancer to global health applications.
 Stevens MM, George JH, Exploring and engineering the cell surface interface., Science, 2005, Vol:310, Pages:1135-1138.
 Howes PD, Chandrawati R, Stevens MM, 2014, Colloidal nanoparticles as advanced biological sensors, Science, 2013, Vol:346, DOI: 10.1126/science.1247390.